Endocrine Abstracts

Background and objective: 111In-DPTA-Octreotide (Octreoscan) has limited spatial resolution and a somewhat lower receptor affinity of the radiopeptide compared to DOTATATE, a novel somatostatin analogue, which can be radiolabelled with 68Ga and adapted for PET imaging, resulting in an increased spatial resolution. The aim of this study was to evaluate the diagnostic performance of 68Ga-DOTATATE PET in patients with NET and to compare this tecni...

Background and objective: Pituitary adenomas (PAs) affect about half of the patients with multiple endocrine neoplasia type 1 (MEN1); in the most of cases PA is a PRL-oma and generally more aggressive than the sporadic form. The aim of this study is to evaluate the recent changes in clinical presentation and therapeutic approach of MEN1-related PAs.Patients and methods: The study population included 17 patients with MEN1-related PA followed-up between 19...

Introduction and aim: Primary hyperparathyroidism (PHP) is the most frequent endocrine abnormality in MEN1 affecting about 100% of cases and inducing severe bone and kidney complications. Although surgery represents the only curative approach in MEN1 PHP, novel drugs are now available to effectively control PHP. The objective of this study was to show the recent changes in clinical presentation and therapeutic approach in MEN1-related PHP occurred in the last years.<p clas...

Context: Neuroendocrine tumors (NETs) are rare neoplasms, heterogeneous, with variable biological behaviour. NETs can be sporadic or they can arise in complex endocrine hereditary syndromes such as Multiple Endocrine Neoplasias (MEN), Familial Paragangliomatosis (FPGL), Neurofibromatosis type 1 (NF1), von Hippel-Lindau Disease (VHL), Tuberous Sclerosis (TSC) and Carney Complex (CC). By performing genetic screening, patients with hereditary NETs can be identified before the dev...

To date, studies focusing on long-term cardiovascular risk (CVR) of polycystic ovary syndrome (PCOS) women are not available, as well as longitudinal data regarding the endothelial structure and function.The aim of this observational study was to examine both endothelial structure and function in young women with PCOS at 5-year follow-up.Thirty PCOS women (age 22.2±2.5 years, mean±S.D.; BMI 22.4±2.1, k...

Clomiphene citrate (CC) is the first-line therapy for inducing ovulation in infertile women with polycystic ovary syndrome (PCOS), but about 20% of them results un-responsive. Lifestyle modification programs are effective in restoring ovarian function and improving reproductive outcomes in PCOS patients.The aim of the present randomized controlled trial was to test the hypothesis that a very short-term intervention consisting in structured exercise train...

Objective: The impact of first-line somatostatin analogues (SSA) on glucose tolerance in acromegaly was investigated during a 10 year period.Patients: One hundred and twelve patients treated with depot SSA.Outcome measures: Primary outcome measures were fasting glucose levels. Data were analyzed according with baseline glucose tolerance and disease control.Results after 12 months SSA treatment: In the 63 pati...

GH replacement is widely used in adults with hypopituitarism, but its effect on tumor occurrence and pituitary tumor recurrence is unknown. Furthermore, in literature there are scant with short follow-up time. The available data do not seem to suggest that rhGH replacement increased the incidence of regrowth of pituitary tumor and of cancer in adults with GHD, provided that IGF-1 concentrations remain within the normal range for age.The aim of our study ...

Aim: To address the role of FDG/PET-CT in the follow-up of DTC.Methods: About 110 consecutive patients (86 female, 24 male, mean age 45±13 years), with DTC were selected between 1999 and 2006. All patients underwent total thyroidectomy, radioiodine ablation and had undetectable serum thyroglobulin (Tg) during L-T4 suppressive therapy and negative serum TgAb. The follow-up included a yearly clinical examination with n...

Elevated insulin levels are correlated with colonic adenomas and carcinomas in the general population. Patients with acromegaly are considered at high risk to develop colonic lesions and have a high insulin levels. To evaluate the role of insulin levels on colonic polyps (hyperplastic, adenomatous, single or synchronous) or adenocarcinoma in acromegaly we designed this analytical, observational, open, prospective, study enrolling 189 patients (100 women, 89 men, age 20–82...